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Detection of Human Parvovirus B19 Infection in First-Trimester Fetal Loss

From the Division of Obstetrics and Gynecology, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden; and Departments of Clinical Virology and Obstetrics and Gynecology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

Address reprint requests to: Kristina Broliden, MD, PhD, Karolinska Institutet, Huddinge University Hospital, Department of Clinical Virology, F68, Stockholm, S-141 86, Sweden; E-mail: kristina.broliden{at}viruslab.hs.sll.se.

OBJECTIVE: To investigate the frequency of parvovirus B19 infection in first-trimester fetal loss, as measured by B19 DNA polymerase chain reaction in placental tissue in a prospective descriptive study from a nonendemic area.

METHODS: Placental tissues from first-trimester fetal losses were examined for presence of B19 DNA by polymerase chain reaction in a prospective study during 30 months. For comparison, placental tissues from second-trimester fetal losses, as well as from full-term normal pregnancies, were also studied.

RESULTS: B19 DNA was detected by polymerase chain reaction in one of 36 (3%) placental tissues from first-trimester fetal losses. In second-trimester fetal losses, eight of 64 (12%) samples were B19 DNA positive. None of the 53 placental tissues from full-term normal pregnancies were B19 DNA positive. In first-trimester fetal losses, maternal serum from the B19 DNA-positive sample was B19 immunoglobulin (Ig)G positive but B19 IgM negative. In second-trimester fetal losses, six of six tested B19 DNA-positive samples were both B19 IgG and IgM positive.

CONCLUSION: The frequency of first-trimester fetal loss associated with parvovirus B19 infection was low, 3%, during a nonepidemic period in Sweden, as measured by B19 DNA-specific polymerase chain reaction in placental tissue.

This article has been cited by other articles:

				M. S. Amstey and K. Broliden Detection of Human Parvovirus B19 Infection in First-Trimester Fetal Loss Obstet. Gynecol., October 1, 2002; 100(4): 831 - 832. [Full Text] [PDF]