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Relation Between Adenosine and T-helper 1/T-helper 2 Imbalance in Women With Preeclampsia

From the Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan; and the Center for Perinatal Biology, Loma Linda University, Loma Linda, California.

Address reprint requests to: Yoshio Yoneyama, MD, Nippon Medical School, Department of Obstetrics and Gynecology, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan; E-mail: Yoshi-1{at}nms.ac.jp.

OBJECTIVE: To evaluate the relationship between changes in plasma adenosine concentration and imbalances in the T-helper 1/T-helper 2 ratio in peripheral blood of women with preeclampsia.

METHODS: Plasma adenosine concentrations and the T-helper 1/T-helper 2 ratio were examined in the peripheral blood of 16 preeclamptic and normal pregnant women. The proportion of specific T-cell marker CD4-positive cells expressing intracellular cytokines, interferon- derived from T-helper 1 and interleukin-4 derived from T-helper 2 cells, were analyzed by flow cytometry. The ratio of interferon- secreting cells to interleukin-4 secreting cells was taken as the T-helper 1/T-helper 2 ratio in vivo. The effect of the adenosine-receptor blocker 8-sulfophenyltheophyl-line was also measured in vitro.

RESULTS: Mean plasma adenosine concentration in preeclampsia was significantly higher than that in normal pregnancy (0.68 ± 0.07 µmol/L versus 0.39 ± 0.06 µmol/L, P < .05). The proportions of interferon- secreting cells increased and interleukin-4 secreting cells decreased significantly in preeclampsia, and the T-helper 1/T-helper 2 ratio in preeclampsia was significantly higher than in normal pregnancy (18.1 ± 2.6 versus 9.9 ± 1.5, P < .05). The increase of the proportion of interferon- secreting cells after adenosine receptor blockade in preeclampsia significantly exceeded that of normal pregnancy. The T-helper 1/T-helper 2 ratio in preeclampsia was significantly greater than that in normal pregnancy (36% versus 17%, P < .05).

CONCLUSION: Increased plasma adenosine may be involved in the regulation of imbalances in the T-helper 1/T-helper 2 ratio in women with preeclampsia.

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