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Obstetrics & Gynecology 2002;99:419-425
© 2002 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Over-the-Counter Antifungal Drug Misuse Associated With Patient-Diagnosed Vulvovaginal Candidiasis

Daron G. Ferris, MD, Paul Nyirjesy, MD, Jack D. Sobel, MD, David Soper, MD, Adriana Pavletic, MD and Mark S. Litaker, PhD

From the Departments of Family Medicine and Obstetrics and Gynecology, and Office of Biostatistics, Medical College of Georgia, Augusta, Georgia; Department of Obstetrics and Gynecology, Jefferson Medical College, Philadelphia, Pennsylvania; Department of Internal Medicine, Wayne State University, Detroit, Michigan; Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina; and Department of Family Medicine, University of Nebraska, Omaha, Nebraska.

Address reprint requests to: Daron G. Ferris, MD, Medical College of Georgia, Departments of Family Medicine and Obstetrics and Gynecology, 1423 Harper Street, HH-100, Augusta, GA 30912; E-mail: dferris{at}mail.mcg.edu.

OBJECTIVE: To estimate what proportion of symptomatic women purchasing over-the-counter antifungal products for immediate treatment of presumed vulvovaginal candidiasis have vulvovaginal candidiasis or other genitourinary conditions.

METHODS: A time-location sample of 95 symptomatic women who purchased and presented with an over-the-counter antifungal product for immediate and personal treatment of presumed vulvovaginal candidiasis were evaluated by clinical examination and pertinent laboratory tests. The percentage of women diagnosed having vulvovaginal candidiasis or other conditions, proportions of women with vulvovaginal candidiasis compared between groups with and without a prior diagnosis of vulvovaginal candidiasis, and groups that read or did not read the over-the-counter package label were assessed.

RESULTS: The actual diagnoses for women who self-diagnosed vulvovaginal candidiasis were: vulvovaginal candidiasis 33.7%, bacterial vaginosis 18.9%, mixed vaginitis 21.1%, normal 13.7%, other diagnoses 10.5%, and trichomonas vaginitis 2.1%. Women with a previous clinically based diagnosis of vulvovaginal candidiasis were not more accurate in diagnosing vulvovaginal candidiasis than women without a prior clinical diagnosis ({chi}2 = 0.27, P = .6). Women who read the package label were no more likely to have vulvovaginal candidiasis than were women who did not read the label (Fisher exact test, P = .39).

CONCLUSION: Many women who self-diagnose and use an over-the-counter product for treatment of presumed vulvovaginal candidiasis do not have vulvovaginal candidiasis. A history of a previous clinically based diagnosis of vulvovaginal candidiasis and reading the package label do not help women self-diagnose vulvovaginal candidiasis properly. Ready access to these products is associated with wasted financial expenditures, unfulfilled expectations, and a delay in correct diagnosis for a substantial number of women.




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