| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH |
From the Department of Gynecology, Escola Paulista de Medicina/Federal University of Sao Paulo, Sao Paulo, Brazil.
Address reprint requests to: Edmund C. Baracat, MD, PhD, Federal University of Sao Paulo, Department of Gynecology, Rua Dr. Diogo de Faria, 1087 cj. 610 v. Clementino, Sao Paulo SP 04037-003, Brazil; E-mail: baracat.toco{at}epm.br
OBJECTIVE: To examine the change in menopausal symptoms and cardiovascular risk factors in response to 4 months of daily 100-mg soy isoflavone in postmenopausal women.
METHODS: In this double-blind, placebo-controlled study, 80 women were randomly assigned to isoflavone (n = 40) and placebo (n = 40) treatment. The menopausal Kupperman index was used to assess change in menopausal symptoms at baseline and after 4 months of treatment. Cardiovascular risk factors were assessed by evaluating plasma lipid levels, body mass index, blood pressure, and glucose levels in the participants. To examine the effects of this regime on endogenous hormone levels, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and 17ß-estradiol were measured. Transvaginal sonography was performed to quantify endometrial thickness.
RESULTS: The data showed a decrease in menopausal symptoms (P < .01, paired t test, two-tailed, between baseline and isoflavone groups, and P < .01, unpaired t test, between placebo and isoflavone groups). Total cholesterol and low-density lipoprotein decreased significantly in the isoflavone group compared with the baseline or placebo group (P < .001, paired t test, two-tailed, between baseline and isoflavone groups, and P < .01, unpaired t test, between placebo and isoflavone groups). The isoflavone treatment appeared to have no effect on blood pressure, plasma glucose, and high-density lipoprotein and triglyceride levels.
CONCLUSION: This study suggests that isoflavone 100-mg regime treatment may be a safe and effective alternative therapy for menopausal symptoms and may offer a benefit to the cardiovascular system.
This article has been cited by other articles:
|
|
 |
|
  F. K. Welty, K. S. Lee, N. S. Lew, and J.-R. Zhou Effect of Soy Nuts on Blood Pressure and Lipid Levels in Hypertensive, Prehypertensive, and Normotensive Postmenopausal Women Arch Intern Med, May 28, 2007; 167(10): 1060 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Michaud, J. P. Karpinski, K. L. Jones, and J. Espirito Dietary supplements in patients with cancer: Risks and key concepts, part 2 Am. J. Health Syst. Pharm., March 1, 2007; 64(5): 467 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Newton, S. D. Reed, A. Z. LaCroix, L. C. Grothaus, K. Ehrlich, and J. Guiltinan Treatment of Vasomotor Symptoms of Menopause with Black Cohosh, Multibotanicals, Soy, Hormone Therapy, or Placebo: A Randomized Trial Ann Intern Med, December 19, 2006; 145(12): 869 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nedrow, J. Miller, M. Walker, P. Nygren, L. H. Huffman, and H. D. Nelson Complementary and alternative therapies for the management of menopause-related symptoms: a systematic evidence review. Arch Intern Med, July 24, 2006; 166(14): 1453 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. D. Nelson, K. K. Vesco, E. Haney, R. Fu, A. Nedrow, J. Miller, C. Nicolaidis, M. Walker, and L. Humphrey Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA, May 3, 2006; 295(17): 2057 - 2071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. T. van der Schouw, L. Sampson, W. C. Willett, and E. B. Rimm The Usual Intake of Lignans but Not That of Isoflavones May Be Related to Cardiovascular Risk Factors in U.S. Men J. Nutr., February 1, 2005; 135(2): 260 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Williamson and C. Manach Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies Am. J. Clinical Nutrition, January 1, 2005; 81(1): 243S - 255S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Krebs, K. E. Ensrud, R. MacDonald, and T. J. Wilt Phytoestrogens for Treatment of Menopausal Symptoms: A Systematic Review Obstet. Gynecol., October 1, 2004; 104(4): 824 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Tice, B. Ettinger, K. Ensrud, R. Wallace, T. Blackwell, and S. R. Cummings Phytoestrogen Supplements for the Treatment of Hot Flashes: The Isoflavone Clover Extract (ICE) Study: A Randomized Controlled Trial JAMA, July 9, 2003; 290(2): 207 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Piersen Phytoestrogens in Botanical Dietary Supplements: Implications for Cancer Integr Cancer Ther, June 1, 2003; 2(2): 120 - 138. [Abstract] [PDF]
|
|
|
|
|
|
E. Nikander, A. Kilkkinen, M. Metsa-Heikkila, H. Adlercreutz, P. Pietinen, A. Tiitinen, and O. Ylikorkala A Randomized Placebo-Controlled Crossover Trial With Phytoestrogens in Treatment of Menopause in Breast Cancer Patients Obstet. Gynecol., June 1, 2003; 101(6): 1213 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Kurzer Phytoestrogen Supplement Use by Women J. Nutr., June 1, 2003; 133(6): 1983S - 1986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 OTHER ARTICLES NOTED (Nov 01 to 18 Oct 02) Evid. Based Nurs., January 1, 2003; 6(1): e1 - 1. [Full Text] [PDF]
|
|
|
|
|
|
F. Kronenberg and A. Fugh-Berman Complementary and Alternative Medicine for Menopausal Symptoms: A Review of Randomized, Controlled Trials Ann Intern Med, November 19, 2002; 137(10): 805 - 813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Warren The Effects of Phytoestrogen Supplementation in Postmenopausal Women Reproductive Sciences, July 1, 2002; 9(4): 184 - 185. [PDF]
|
|
|
|
 |
|
 Another Look at Isoflavones for Menopausal Symptoms Journal Watch Women's Health, June 18, 2002; 2002(618): 4 - 4. [Full Text]
|
|
|
|
 |
|
 Soy Isoflavones Reduce Menopausal Symptoms Journal Watch Psychiatry, May 23, 2002; 2002(523): 10 - 10. [Full Text]
|
|
|
|
 |
|
 Soy Isoflavones Reduce Menopausal Symptoms Journal Watch (General), April 9, 2002; 2002(409): 4 - 4. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
