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ORIGINAL RESEARCH |
From the Early Pregnancy & Gynaecology Assessment Unit, Kings College Hospital, and Recurrent Miscarriage Clinic, St Marys Hospital, London, United Kingdom.
Address reprint requests to: Davor Jurkovic, MD, PhD, Early Pregnancy and Gynaecology Assessment Unit, Kings College Hospital, Denmark Hill, London SE5 8RX United Kingdom; E-mail: davor.jurkovic{at}kcl.ac.uk.
OBJECTIVE: To determine reproductive outcomes in women with congenital uterine anomalies detected incidentally by three-dimensional ultrasound.
METHODS: We studied 1089 women with no history of infertility or recurrent miscarriage who were seen for a transvaginal ultrasound scan. They were screened for uterine abnormalities using three-dimensional ultrasound. We determined prevalence of miscarriage and preterm labor in women with normal and abnormal uterine morphology.
RESULTS: We found that 983 women had a normally shaped uterine cavity, 72 an arcuate, 29 a subseptate, and five a bicornuate uterus. Women with a subseptate uterus had a significantly higher proportion of first-trimester loss (Z = 4.68, P < .01) compared with women with a normal uterus. Women with an arcuate uterus had a significantly greater proportion of second-trimester loss (Z = 5.76, P < .01) and preterm labor (Z = 4.1, P < .01). There were no other significant differences in pregnancy outcomes between women with normal and abnormal uterine morphology.
CONCLUSION: This study shows the potential value of three-dimensional ultrasound and confirmed that women with congenital uterine anomalies were more likely to have adverse pregnancy outcomes than women with a normal uterus.
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