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Preventing Recurrent Second Trimester Group B Streptococcus Chorioamnionitis by Intermittent Prophylactic Ampicillin

Department of Obstetrics and Gynecology, Alta Bates Medical Center, Berkeley, California

Address reprint requests to: David N. Marinoff, MD, Department of Obstetrics and Gynecology, Alta Bates Perinatal Center, 5730 Telegraph Avenue, Oakland, CA 94609.

BACKGROUND: Whereas carrying group B streptococcus during pregnancy is common, second trimester group B streptococcus chorioamnionitis with intact membranes is rare, and recurrence of the latter problem even more so.

CASE: A 38-year-old multipara with a history of recurrent second trimester group B streptococcus chorioamnionitis resulting in pregnancy loss was treated, beginning at 14 weeks’ gestation, with monthly prophylactic ampicillin therapy throughout pregnancy and delivered a healthy male infant at term.

CONCLUSION: In women with recurrent pregnancy loss due to second trimester group B streptococcus chorioamnionitis, an intermittent prophylactic antibiotic regimen throughout pregnancy might increase the probability of successful pregnancy.