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Serum Soluble Fas Levels in Preeclampsia

From the Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska; the Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas; and the Department of Obstetrics and Gynecology, Yale-New Haven Hospital, New Haven, Connecticut.

Address reprint requests to: Chaur-Dong Hsu, MD, MPH Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, 983255 Nebraska Medical Center, Omaha, NE 68198-3255, E-mail: cdhsu{at}unmc.edu

Objective: To determine if serum soluble Fas levels are altered in women with preeclampsia.

Methods: Thirty-four pregnant women with preeclampsia and 34 normotensive pregnant women were studied. Subjects were matched as much as possible for demographics. Preeclampsia was defined as proteinuric hypertension. Serum soluble Fas levels were measured by enzyme-linked immunoassay. Two-tailed Student t test, ² test, Pearson correlation coefficients, and analysis of variance with post hoc test were used for statistical analyses.

Results: Mean serum soluble Fas levels were significantly higher in preeclamptic than normotensive women (10.59 ± 0.68 U/mL versus 5.65 ± 0.35 U/mL, P < .001).

Conclusion: Elevated serum soluble Fas is associated with preeclampsia. Such elevation might indicate protection of maternal T-lymphocyte apoptosis and consequently lead to the maternal immune intolerance noted in preeclampsia.

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