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Obstetrics & Gynecology 2001;97:316-317
© 2001 by The American College of Obstetricians and Gynecologists
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CLINICAL COMMENTARY

REPEATED COURSES OF ANTENATAL CORTICOSTEROIDS

Robert L. Goldenberg, MD and Linda L. Wright, MD

From the Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama; and the Center for Research for Mothers and Children, NICHD, Bethesda, Maryland.

Address reprint requests to: Robert L. Goldenberg, MD University of Alabama at Birmingham Department of Obstetrics and Gynecology 619 3rd Avenue South, CIRC 320 Birmingham, AL 35294-0021 E-mail: rlg{at}uab.edu

A single course of corticosteroids given to women before an anticipated preterm birth reduces the incidence of respiratory distress syndrome, intraventricular hemorrhage, and neonatal death. For women who do not deliver within 1 week, repeated courses of corticosteroids have become common obstetric practice, despite little evidence of efficacy. Emerging data suggest little benefit and potential harm from that practice, so corticosteroids to improve perinatal outcomes should be restricted to a single course unless future randomized trial data prove additional courses to be beneficial.




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