Obstetrics & Gynecology Email Alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Obstetrics & Gynecology 2001;97:220-224
© 2001 by The American College of Obstetricians and Gynecologists
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by NACCASHA, N.
Right arrow Articles by MITTENDORF, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NACCASHA, N.
Right arrow Articles by MITTENDORF, R.

ORIGINAL RESEARCH

Association Between Funisitis and Elevated Interleukin-6 in Cord Blood

NIHAL NACCASHA, MD, ROGER HINSON, MD, ANTHONY MONTAG, MD, MAHMOUD ISMAIL, MD, LYNN BENTZ, RN and ROBERT MITTENDORF, MD, DrPH

From the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan; Section of Neonatology, Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Departments of Pathology and Obstetrics and Gynecology, University of Chicago, Chicago, Illinois; and Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois.

Address reprint requests to: Robert Mittendorf, MD, DrPH Department of Obstetrics and Gynecology Loyola University Medical Center 2160 South First Avenue Maywood, IL 60153 E-mail: rmitten{at}luc.edu

Objective: To determine whether elevated plasma interleukin-6 (IL-6) in umbilical venous cord blood at delivery is associated with funisitis and whether IL-6 can be used to screen for funisitis in preterm neonates.

Methods: At the time of delivery, umbilical venous cord blood samples were collected from 92 infants for whom placental pathology results were also available. Interleukin-6 concentrations in the umbilical venous cord blood plasma were measured by immunoassay. Histologic examinations of the placenta and umbilical cord were done to determine the presence or absence of funisitis and chorioamnionitis. For a power of 90% with an {alpha} of .05, 12 subjects were required in each group.

Results: We found a significant association between the presence of histologic funisitis and elevated umbilical venous cord blood plasma IL-6 concentrations (defined as 10 pg/mL or greater). Of 15 infants whose umbilical cords showed funisitis, 93% (14 of 15) had elevated umbilical venous cord blood plasma IL-6 concentrations. Of 77 infants without funisitis, 32% (25 of 77) had elevated IL-6 concentrations in their cords (P < .001, two-sided Fisher exact test). The negative predictive value of IL-6 as a screening test for funisitis was 98%.

Conclusion: In preterm neonates, screening for funisitis by using the immunoassay for IL-6 appears to be valid. In the near future, elevated umbilical venous cord blood IL-6 concentrations at delivery could be clinically useful to identify children who might benefit from early treatment for systemic fetal inflammatory syndrome.




This article has been cited by other articles:


Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
Y D Kim, W Y Hyun, and H J Cha
Funisitis and raised interleukin 6 concentrations in gastric aspirates at birth
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2005; 90(4): F349 - f350.
[Full Text] [PDF]

Home page
 Obstet GynecolHome page
R. K. Freeman
Problems With Intrapartum Fetal Heart Rate Monitoring Interpretation and Patient Management
Obstet. Gynecol., October 1, 2002; 100(4): 813 - 826.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American College of Obstetricians and Gynecologists.