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ORIGINAL RESEARCH |
From the Departments of Obstetrics and Gynecology and Clinical Biochemistry, Soroka University Medical Center and Temple University, Philadelphia, Pennsylvania; and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Address reprint requests to: Arnon Wiznitzer, MD Soroka University Medical Center Department of Obstetrics and Gynecology P.O. 151 Beer-Sheva Israel
Objective: To determine the relationships among serum leptin, insulin-like growth factor-I, and insulin levels in large for gestational age (LGA) infants.
Methods: Serum samples were collected from maternal veins and umbilical arteries of 52 consecutive, term, LGA neonates of nondiabetic mothers. Maternal and neonatal serum samples were analyzed for levels of leptin, insulin-like growth factor-I, and insulin by specific radioimmunoassays. Multiple regression analysis was used to determine independent risk factors for fetal macrosomia.
Results: The independent risk factor significantly associated with fetal macrosomia was umbilical cord leptin concentration (P < .01, ß = 0.59). There was a statistically significant correlation between umbilical cord leptin and insulin-like growth factor-I levels and birth weight (r = 0.51, P < .01; r = 0.37, P < .01; respectively). The correlation between umbilical cord insulin levels and birth weight was not statistically significant (r = 0.06, P = .63), nor was that between maternal body mass index and birth weight (r = 0.09, P = .50).
Conclusion: Our data showed that umbilical cord leptin concentration was an independent risk factor for fetal macrosomia.
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