| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH |
From the Department of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas.
Address reprint requests to: Lisa M. Hollier, MD, MPH University of Texas, Houston Department of Obstetrics, Gynecology and Reproductive Science Lyndon Baines Johnson General Hospital 5656 Kelley Street Houston, TX 77026 E-mail: lisa.m.hollier{at}uth.tmc.edu
Objective: To examine the effect of maternal age on incidence of nonchromosomal fetal malformations.
Methods: Malformations detected at birth or in the newborn nursery were catalogued prospectively for 102,728 pregnancies, including abortions, stillbirths, and live births, from January 1, 1988 to December 31, 1994. Maternal age was divided into seven epochs. Relative risks (RRs) were used to compare demographic variables and specific malformations. The Mantel-Haenszel 
2 statistic was used to compare age-specific anomalies. Multiple logistic regression analysis was used to adjust for parity.
Results: Abnormal karyotypes were significantly more frequent in older women. After excluding infants with chromosomal abnormalities, the incidence of structurally malformed infants also was increased significantly and progressively in women 25 years of age or older. The additional age-related risk of nonchromosomal malformations was approximately 1% in women 35 years of age or older. The odds ratio for cardiac defects was 3.95 in infants of women 40 years of age or older (95% CI 1.70, 9.17) compared with women aged 20–24 years. The risks of clubfoot and diaphragmatic hernia also increased as maternal age increased.
Conclusion: Advanced maternal age beyond 25 years was associated with significantly increased risk of fetuses having congenital malformations not caused by aneuploidy.
This article has been cited by other articles:
|
|
 |
|
  Update on Overall Prevalence of Major Birth Defects--Atlanta, Georgia, 1978-2005 JAMA, February 20, 2008; 299(7): 756 - 758. [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Ray, M. J. Vermeulen, and G. Koren Taking ACE inhibitors during early pregnancy: Is it safe? Can Fam Physician, September 1, 2007; 53(9): 1439 - 1440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-K. Chen, S. W. Wen, N. Fleming, Q. Yang, and M. C. Walker Teenage pregnancy and congenital anomalies: which system is vulnerable? Hum. Reprod., June 1, 2007; 22(6): 1730 - 1735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S C Huynh, X Y Wang, J Ip, D Robaei, A Kifley, K A Rose, and P Mitchell Prevalence and associations of anisometropia and aniso-astigmatism in a population based sample of 6 year old children Br. J. Ophthalmol., May 1, 2006; 90(5): 597 - 601. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
