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Lidocaine Spray and Outpatient Hysteroscopy: Randomized Placebo-Controlled Trial

From the Service de Gynécologie, Hôpital Hôtel-Dieu de Paris, Université Paris, Paris, France.

Address reprint requests to: Emile Daraï, MD Hôpital Hôtel-Dieu de Paris Service de Gynecologie 2 rue d’Arcole 75004 Paris France E-mail: emile.darai{at}htd.ap-hop-paris.fr

Objective: To assess the efficacy of lidocaine spray during outpatient hysteroscopy for reducing procedure-related pain and to identify risk factors for discomfort.

Methods: One hundred twenty-one women were assigned randomly to have application of lidocaine spray or placebo to the uterine cervix during outpatient hysteroscopy. The main outcome measure was pain during hysteroscopy, assessed on a visual analog scale.

Results: There was no statistically significant difference between study and control groups in mean age, rate of nulliparity, postmenopausal state, need for cervical dilation, or percentage of women who used hormone replacement therapy. Indications for diagnostic hysteroscopy were similar between groups. Women in the lidocaine group had statistically significantly less pain during the procedure than women in the placebo group (2.2 ± 1.9 and 3.7 ± 2.5, respectively; P < .001). Women with abnormal uterine findings (submucous myoma, endometrial polyps, or intrauterine adhesions) had significantly higher pain scores than women with normal cavities (2.2 ± 1.9 and 3.2 ± 2.4, respectively; P < .002). Aerosol anesthesia and normal uterine findings were independently associated with less pain. No procedure had to be abandoned because of excessive pain or complications, and no women required hospitalization.

Conclusion: Women treated with lidocaine spray had significantly less pain. Uterine cavity abnormality might be associated with a higher degree of pain during hysteroscopy.

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