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Relation Between Serum Uric Acid and Plasma Adenosine Levels in Twin Pregnancies

From the Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.

Address reprint requests to: Shunji Suzuki, MD Department of Obstetrics and Gynecology Nippon Medical School 1-1-5 Sendagi, Bunkyo-ku Tokyo 113 Japan

Objective: To examine the relationship between plasma adenosine and serum uric acid levels in women with singleton and twin pregnancies.

Methods: We sampled maternal arterial blood and measured serum uric acid and plasma adenosine levels in 22 singleton pregnancies and nine twin pregnancies at 33 to 38 weeks’ gestation.

Results: The average plasma adenosine levels were 0.31 ± 0.12 µmol/L in the singleton pregnancy group and 0.45 ± 0.09 µmol/L in the twin pregnancy group (P < .001). The mean serum uric acid level in women with twin pregnancy was 5.7 ± 0.44 mg/dL which was higher than that in the singleton pregnant women (4.4 ± 0.69 mg/dL, P < .001). Positive correlations were found between serum uric acid and plasma adenosine levels in both the singleton (r² = 0.54, P < .001) and the twin pregnancy groups (r² = 0.65, P = .009). Moreover, there was also a significant correlation between serum uric acid and plasma adenosine levels overall (r² = 0.66, P < .001).

Conclusion: Our results suggest that higher adenosine levels are a contributing source of hyperuricemia in twin pregnancies.

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