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Obstetrics & Gynecology 2000;96:470-472
© 2000 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Spontaneous Regression of Vulvar Intraepithelial Neoplasia 2-3

RONALD W. JONES, FRCS, FRCOG and DARION M. ROWAN, FACD

From the Vulvar Clinic, Department of Gynecologic Oncology, National Women’s Hospital, Auckland, New Zealand.

Address reprint requests to: Ronald W. Jones, FRCS, FRCOG PO Box 26090 EPSOM Auckland 3 New Zealand

Objective: To determine the background and clinical features of a group of women who experienced spontaneous regression of vulvar intraepithelial neoplasia (VIN) 2-3 before treatment was undertaken.

Methods: A retrospective review was made of the records of 14 women who experienced spontaneous regression of VIN 2-3.

Results: The women were 15–27 years of age (median 19.5 years). Ninety-three percent were non-white. All women were seen initially in a sexual health clinic, and with one exception, all had been treated previously for genital condyloma acuminata. Four of the 14 cases were pregnancy-associated. Half of the women were asymptomatic. The transit time to regression of VIN 2-3 was 3–30 months (median 9.5 months). The median follow-up was 3 years. All lesions were multiple and pigmented.

Conclusion: Spontaneous regression of VIN 2-3 can occur in young women with multifocal pigmented lesions.




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