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Obstetrics & Gynecology 2000;96:417-421
© 2000 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Absence of Estrogen Receptor-ß Expression in Metastatic Ovarian Cancer

THOMAS RUTHERFORD, MD, PhD, WENDI D. BROWN, MD, EVA SAPI, PhD, SARIT ASCHKENAZI, MD, AMANDA MUÑOZ and GIL MOR, MD, PhD

From the Departments of Obstetrics and Gynecology, and Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut.

Address reprint requests to: Gil Mor, MD, PhD Yale University School of Medicine Department of Obstetrics and Gynecology 333 Cedar Street, FMB 202 New Haven, CT 06520 E-mail: gil.mor{at}yale.edu

Objective: To evaluate the expression of estrogen receptor (ER){alpha} and ERß mRNA and protein in normal ovarian tissue and primary and metastatic tumors.

Methods: Estrogen receptor {alpha} and ERß expression was studied in normal ovarian biopsies (n = 9) and primary (n = 8) and metastatic ovarian epithelial cancers (n = 8). Ovarian tissue was collected from surgical samples. Estrogen receptor {alpha} and ERß mRNA expression was compared by coamplification of the mRNA of the ERs. Expression was confirmed at the protein level by Western blot analysis using antibodies specific for each receptor.

Results: Among eight primary ovarian cancer samples, three had only ER{alpha}, two had only ERß, and three had both. All eight metastatic ovarian cancer tissues expressed only ER{alpha} mRNA and protein. Biopsies from normal ovaries had ER{alpha} and ERß mRNA and protein. Two of the ovarian epithelial cancer samples were paired and showed the same results.

Conclusion: We found varying amounts of ER{alpha} and ERß in normal ovaries, lower levels of ERß expression in ovarian epithelial cancer primary tumors, and only ER{alpha} in metastatic tumors. Our findings indicate that a fundamental difference might exist between primary and metastatic cells, which could be caused by intrinsic or extrinsic factors that regulate ER gene expression.




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