HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by HIETALA, R. Articles by LAATIKAINEN, T. Search for Related Content PubMed PubMed Citation Articles by HIETALA, R. Articles by LAATIKAINEN, T.

Serum Insulin-Like Growth Factor Binding Protein-1 at 16 Weeks and Subsequent Preeclampsia

From the Helsinki City Maternity Hospital and Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland.

Address reprint requests to: Timo Laatikainen, MD, PhD Helsinki City Maternity Hospital Sofianlehdonkatu 5A Helsinki, 00610 Finland

Objective: To determine whether serum concentrations of insulin-like growth factor-binding protein-1 (IGFBP-1), a major decidual protein, at 16 weeks’ gestation differ between women who later develop pregnancy-related hypertension and normotensive women.

Methods: Concentrations of IGFBP-1 were measured using immunoenzymometric assay in serum samples collected for alpha-fetoprotein (AFP) and free ß subunit of hCG (free ß-hCG) determinations in a Down syndrome screening program at 16 weeks’ gestation in a population-based cohort of 1049 nulliparous women. After exclusion of subjects with multiple pregnancies, insulin-dependent diabetes, major fetal malformations, and incomplete data, 917 subjects remained eligible.

Results: The mean levels (± standard deviation) of IGFBP-1 were significantly lower in 34 women who later developed preeclampsia (73 ± 43 µg/L, P < .01) and in 80 women with White A diabetes (84.7 ± 53 µg/L, P < .01) compared with controls (103 ± 58 µg/L). In seven women with White A diabetes and subsequent preeclampsia IGFBP-1 levels were especially low (41 ± 34 µg/L). The concentrations of AFP and free ß-hCG in the subgroups with hypertensive disorders were not significantly different from those of normotensive women.

Conclusion: Decreased IGFBP-1 levels at 16 weeks’ gestation in women who develop preeclampsia might indicate impaired decidual function. Hyperinsulinemia, a known risk factor for preeclampsia, might contribute to decreased concentrations of serum IGFBP-1. However, due to low sensitivity, assay of serum IGFBP-1 was not clinically valuable for predicting preeclampsia.

This article has been cited by other articles:

				L. J Vatten, T. I L Nilsen, A. Juul, S. Jeansson, P. A Jenum, and A. Eskild Changes in circulating level of IGF-I and IGF-binding protein-1 from the first to second trimester as predictors of preeclampsia Eur. J. Endocrinol., January 1, 2008; 158(1): 101 - 105. [Abstract] [Full Text] [PDF]

				K.-A. Wathen, E. Tuutti, U.-H. Stenman, H. Alfthan, E. Halmesmaki, P. Finne, O. Ylikorkala, and P. Vuorela Maternal Serum-Soluble Vascular Endothelial Growth Factor Receptor-1 in Early Pregnancy Ending in Preeclampsia or Intrauterine Growth Retardation J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 180 - 184. [Abstract] [Full Text] [PDF]

				F. M. Reis, D. D'Antona, and F. Petraglia Predictive Value of Hormone Measurements in Maternal and Fetal Complications of Pregnancy Endocr. Rev., April 1, 2002; 23(2): 230 - 257. [Abstract] [Full Text] [PDF]

				W. A. GROBMAN and R. R. KAZER Serum Insulin, Insulin-Like Growth Factor-I, and Insulin-Like Growth Factor Binding Protein-1 in Women Who Develop Preeclampsia Obstet. Gynecol., April 1, 2001; 97(4): 521 - 526. [Abstract] [Full Text] [PDF]

				R. HIETALA, U. TURPEINEN, and T. LAATIKAINEN Serum Homocysteine at 16 Weeks and Subsequent Preeclampsia Obstet. Gynecol., April 1, 2001; 97(4): 527 - 529. [Abstract] [Full Text] [PDF]