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Obstetrics & Gynecology 2000;95:29-33
© 2000 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Platelet Count at Term Pregnancy: A Reappraisal of the Threshold

FRANÇOISE BOEHLEN, MD, PATRICK HOHLFELD, MD, PHILIPPE EXTERMANN, MD, THOMAS V. PERNEGER, MD and PHILIPPE DE MOERLOOSE, MD

From the Division of Angiology and Haemostasis, Department of Internal Medicine, University Hospital, Geneva; the Department of Gynecology and Obstetrics, University Hospital, Lausanne; the Department of Gynecology and Obstetrics, University Hospital, Geneva; and the Institute of Social and Preventive Medicine and Quality of Care Unit, Geneva, Switzerland.

Address reprint requests to: Philippe de Moerloose, MD, Haemostasis Unit. University Hospital of Geneva Geneva, 1211 14, Switzerland E-mail: philippe.demoerloose{at}hcuge.ch

Objective: To assess the safety of a new platelet count threshold for the definition of maternal thrombocytopenia late in pregnancy.

Methods: A platelet count was performed in 6770 pregnant women late in pregnancy and in 6103 of their newborns as well as in a control group of 287 age-matched nonpregnant healthy women.

Results: The prevalence of maternal thrombocytopenia (platelet count less than 150 x 109/L) was 11.6%. The mean platelet counts (248 compared with 213 x 109/L) and 2.5th percentile (164 compared with 116 x 109/L) were significantly higher in healthy nonpregnant women than in pregnant women. Among thrombocytopenic pregnant women, 621 (79%) had platelet counts between 116 and 149 x 109/L; none (0%; 95% confidence interval 0, 0.6) had complications related to thrombocytopenia, and none of their newborns had severe thrombocytopenia (platelet count less than 20 x 109/L).

Conclusion: In healthy pregnant women, a platelet count over 115 x 109/L late in pregnancy does not require further investigation during pregnancy and may be considered a safe threshold.




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