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Endometrial Release of Soluble Intercellular Adhesion Molecule 1 and Endometriosis: Relationship to the Extent of the Disease

From the II Department of Obstetrics and Gynecology, University of Milan and Istituto Auxologico Italiano, Milan, Italy.

Address reprint requests to: Paola Viganò, DSc, II Department of Obstetrics and Gynecology, Clinica "L. Mangiagalli", Via Commenda 12, 20122 Milan, Italy

Objective: To relate endometrial release of the soluble form of intercellular adhesion molecule 1 with extent of endometriosis.

Methods: Samples of endometrium were collected from 23 women with endometriosis. Soluble intercellular adhesion molecule 1 was quantified in conditioned medium from 48-hour endometrial stromal cell cultures with use of a specific enzyme-linked immunosorbent assay. Levels were correlated with revised American Society for Reproductive Medicine classification score for adhesions, implants, and cysts and total score; number of endometriotic implants; cyst diameter; and presence or absence of pelvic pain symptoms and previous surgical procedures for endometriosis.

Results: Endometrial release of soluble intercellular adhesion molecule 1 directly correlated with number of implants (r = .64, P < .005) and score for implants (r = .61, P < .005). There was no significant correlation between levels of the soluble molecule and score for adhesions or total score. Soluble intercellular adhesion molecule 1 shed by endometrium did not correlate with the score for ovarian cysts, although an inverse relationship was found with ovarian cyst diameter (r = -0.52, P < .05). No differences were detected between women who had pelvic pain and those who did not and between those who had previous surgery for endometriosis and those who had not.

Conclusion: The association between endometrial release of soluble intercellular adhesion molecule 1 and the number and score of endometriotic implants suggests that the molecule might be of value in evaluating spread potential of refluxed endometrium.

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