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Obstetrics & Gynecology 1999;93:964-967
© 1999 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Amniotic Fluid Concentrations of Adrenomedullin in Preterm Labor

EMANUELA MARINONI, MD, PhD, ROMOLO DI IORIO, MD, PhD, CLAUDIO LETIZIA, MD, BARBARA VILLACCIO, MD, ALESSANDRO ALBERINI, MD and ERMELANDO V. COSMI, MD

From the Laboratory of Perinatal Medicine and Molecular Biology, 2nd Institute of Obstetrics and Gynecology, and Department of Internal Medicine, University "La Sapienza," Rome, Italy.

Address reprint requests to: Emanuela Marinoni, MD 2nd Institute of Obstetrics and Gynecology University "La Sapienza" Viale Regina Elena, 324 I-00161 Rome Italy E-mail: perinat{at}flashnet.it

Objective: To determine whether adrenomedullin levels in amniotic fluid were associated with preterm labor.

Methods: We measured immunoreactive adrenomedullin in amniotic fluid collected by amniocentesis from 36 women with clinical diagnosis of preterm labor or preterm premature rupture of membranes (PROM) and from 18 normal pregnant women.

Results: Amniotic fluid from cases of PROM and failure to respond to tocolysis were associated significantly with higher amniotic fluid adrenomedullin concentrations (177.0 ± 22.5 pg/mL and 182.7 ± 22.0 pg/mL, respectively, P < .01) than that from uncomplicated pregnancies (101.2 ± 28.1 pg/mL) or preterm labor responsive to tocolysis (102.3 ± 26.8 pg/mL).

Conclusion: Amniotic fluid adrenomedullin is higher than normal in cases of PROM and preterm labor unresponsive to tocolysis, perhaps indicating enhanced synthesis from placenta or fetal membranes being stimulated by bacterial products.




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