| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH |
From the Department of Obstetrics and Gynecology and the Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland.
Address reprint requests to: Hannele Laivuori, MD, Department of Obstetrics and Gynecology, Helsinki University Central Hospital, PO Box 140 FIN-00029 HYKS, Finland, E-mail: hannele.laivuori{at}pp.fimnet.fi
Objective: To study the plasma levels of homocysteine in preeclampsia and relate them to insulin sensitivity.
Methods: In association with a 3-hour intravenous glucose-tolerance test (glucose 0.3 g/kg at 0 and 0.03 IU insulin 20 minutes later), we measured plasma levels of homocysteine, vitamin B12, and folic acid in 22 women with preeclampsia and 16 controls between 29 and 39 weeks’ gestation. In 14 women with preeclampsia and 11 controls, plasma samples also were collected 3 months after delivery.
Results: Levels of homocysteine in women with preeclampsia (6.7 ± 0.4 µmol/L, mean ± standard error) were higher (P < .001) than those in controls (3.8 ± 0.2 µmol/L) and related significantly to the level of proteinuria (r = .49, P = .02). Vitamin B12 concentrations were lower in women with preeclampsia (166.0 ± 10.4 compared with 212.4 ± 16.4 pmol/L, P = .02), whereas levels of folic acid showed no difference between the groups. After delivery, levels of homocysteine increased to 9.1 ± 0.6 and 8.2 ± 0.6 µmol/L in women with preeclampsia and controls, vitamin B12 increased to 298.8 ± 28.6 compared with 334.9 ± 24.0 pmol/l, and folic acid decreased to 10.6 ± 2.0 compared with 7.9 ± 0.8 nmol/L, with no difference emerging between the groups. In women with preeclampsia but not in controls, plasma homocysteine was negatively related to insulin sensitivity (r = -.51, P = .02). The mean 2.9-fold increase in glucose or 52.5-fold increase in insulin during the insulin-sensitivity test failed to affect homocysteine levels.
Conclusion: Women with preeclampsia have high plasma homocysteine levels that are inversely related to insulin sensitivity.
This article has been cited by other articles:
|
|
 |
|
  J. Girouard, Y. Giguere, J.-M. Moutquin, and J.-C. Forest Previous Hypertensive Disease of Pregnancy Is Associated With Alterations of Markers of Insulin Resistance Hypertension, May 1, 2007; 49(5): 1056 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Brown, T. Bottiglieri, C. A. Schaefer, C. P. Quesenberry Jr, L. Liu, M. Bresnahan, and E. S. Susser Elevated Prenatal Homocysteine Levels as a Risk Factor for Schizophrenia Arch Gen Psychiatry, January 1, 2007; 64(1): 31 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tamura and M. F. Picciano Folate and human reproduction Am. J. Clinical Nutrition, May 1, 2006; 83(5): 993 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. O Scholl, M. Leskiw, X. Chen, M. Sims, and T P. Stein Oxidative stress, diet, and the etiology of preeclampsia Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1390 - 1396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Mignini, P. M. Latthe, J. Villar, M. D. Kilby, G. Carroli, and K. S. Khan Mapping the Theories of Preeclampsia: The Role of Homocysteine Obstet. Gynecol., February 1, 2005; 105(2): 411 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Roberts, J. L. Balk, L. M. Bodnar, J. M. Belizan, E. Bergel, and A. Martinez Nutrient Involvement in Preeclampsia J. Nutr., May 1, 2003; 133(5): 1684S - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schachter, A. Raziel, S. Friedler, D. Strassburger, O. Bern, and R. Ron-El Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine Hum. Reprod., April 1, 2003; 18(4): 721 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hernandez-Diaz, M. M. Werler, C. Louik, and A. A. Mitchell Risk of Gestational Hypertension in Relation to Folic Acid Supplementation during Pregnancy Am. J. Epidemiol., November 1, 2002; 156(9): 806 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. HIETALA, U. TURPEINEN, and T. LAATIKAINEN Serum Homocysteine at 16 Weeks and Subsequent Preeclampsia Obstet. Gynecol., April 1, 2001; 97(4): 527 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Sanchez, C. Zhang, M. Rene Malinow, S. Ware-Jauregui, G. Larrabure, and M. A. Williams Plasma Folate, Vitamin B12, and Homocyst(e)ine Concentrations in Preeclamptic and Normotensive Peruvian Women Am. J. Epidemiol., March 1, 2001; 153(5): 474 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. F. Godsland, J. R. Rosankiewicz, A. J. Proudler, and D. G. Johnston Plasma Total Homocysteine Concentrations Are Unrelated to Insulin Sensitivity and Components of the Metabolic Syndrome in Healthy Men J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 719 - 723. [Abstract] [Full Text]
|
|
|
|
|
|
H. LAIVUORI, R. KAAJA, O. YLIKORKALA, T. HILTUNEN, and K. KONTULA 677 C->T Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Preeclampsia Obstet. Gynecol., August 1, 2000; 96(2): 277 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pardo, Y. Peled, J. Bar, M. Hod, B.A. Sela, Z.B. Rafael, and R. Orvieto Evaluation of low serum vitamin B12 in the non-anaemic pregnant patient Hum. Reprod., January 1, 2000; 15(1): 224 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Fonseca, S. C. Guba, and L. M. Fink Hyperhomocysteinemia and the Endocrine System: Implications for Atherosclerosis and Thrombosis Endocr. Rev., October 1, 1999; 20(5): 738 - 759. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
