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Obstetrics & Gynecology 1996;88:110-113
© 1996 by The American College of Obstetricians and Gynecologists
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Articles

Concentrated oxytocin plus low-dose prostaglandin E2 compared with prostaglandin E2 vaginal suppositories for second-trimester pregnancy termination

J Owen and JC Hauth

OBJECTIVE: To examine the efficacy and side effects of concentrated oxytocin plus low-dose prostaglandin (PG) E2 compared with a standard dose of vaginal PGE2 for second-trimester pregnancy termination. METHODS: Patients with obstetric or fetal complications were randomly assigned to receive either a 20-mg PGE2 vaginal suppository every 4 hours (n = 81) or a concentrated oxytocin infusion plus a 10-mg PGE2 vaginal suppository every 6 hours (n = 73). Treatment success was defined as delivery (or imminent delivery) within 24 hours of therapy. Women who failed their assigned regimen were crossed to the alternate method. RESULTS: Indications for delivery were similar in the two groups. The success rate with oxytocin was 89%, compared with 81% with vaginal PGE2 (relative risk 0.92, 95% confidence interval 0.8-1.04; P = .2). Maternal fever (P < .001), nausea (P = .02), and vomiting (P = .003) occurred significantly more often in women who received a 20-mg PGE2 vaginal suppository every 4 hours. CONCLUSION: Concentrated oxytocin plus low-dose PGE2 should be considered as an alternative to vaginal PGE2 for indicated second-trimester pregnancy termination.


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P. S. Ramsey, K. Savage, T. Lincoln, and J. Owen
Vaginal Misoprostol Versus Concentrated Oxytocin and Vaginal PGE2 for Second-Trimester Labor Induction
Obstet. Gynecol., July 1, 2004; 104(1): 138 - 145.
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P. G. Stubblefield, S. Carr-Ellis, and L. Borgatta
Methods for Induced Abortion
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M. B. Munn, J. Owen, R. Vincent, M. Wakefield, D. H. Chestnut, and J. C. Hauth
Comparison of Two Oxytocin Regimens to Prevent Uterine Atony at Cesarean Delivery: A Randomized Controlled Trial
Obstet. Gynecol., September 1, 2001; 98(3): 386 - 390.
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