| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Endocrine Unit, the Department of Pediatrics, Scientific Institute H San Raffaele, University of Milan, Milan, Ital
Abstract
Because a close relationship between estrogen deficiency and osteoporosis has been proven, it is possible that lifelong estrogen deficiency might be the cause of osteopenia in Turner syndrome. This study was done to characterize the effect of estrogen therapy on bone mineralization in girls with Turner syndrome. Radial bone mineral content values were found to be below the 95% normal confidence interval in 44 of 49 untreated patients, aged 10.82±3.45 years. An inverse correlation was found between the patients' ages and their 
bone mineral content values. The effect of beginning estrogen treatment early or late was studied in 16 girls who started the treatment before and 11 who started after age 12. Although they were still deficient compared with controls, the first group had better mineralization than the second (P=.0005). Finally, nine patients were followed prospectively during replacement therapy; their bone mineral content values changed significantly (P=.02) during the follow-up period (3.17± 0.33 years), but the bone mineral content did not normalize. Our data show that estrogen deficiency per se does not cause osteoporosis in young girls with Turner syndrome. In fact, estrogen therapy prevented bone loss but failed to normalize the low bone mineral content values. Early treatment is preferable because it reduces the bone density deficit present in untreated patients.
This article has been cited by other articles:
|
|
 |
|
  W. Hogler, J. Briody, B. Moore, S. Garnett, P. W. Lu, and C. T. Cowell Importance of Estrogen on Bone Health in Turner Syndrome: A Cross-Sectional and Longitudinal Study Using Dual-Energy X-Ray Absorptiometry J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 193 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Gravholt, A. L. Lauridsen, K. Brixen, L. Mosekilde, L. Heickendorff, and J. S. Christiansen Marked Disproportionality in Bone Size and Mineral, and Distinct Abnormalities in Bone Markers and Calcitropic Hormones in Adult Turner Syndrome: A Cross-Sectional Study J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2798 - 2808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Elsheikh, D. B. Dunger, G. S. Conway, and J. A. H. Wass Turner's Syndrome in Adulthood Endocr. Rev., February 1, 2002; 23(1): 120 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ankarberg-Lindgren, M. Elfving, K. A. Wikland, and E. Norjavaara Nocturnal Application of Transdermal Estradiol Patches Produces Levels of Estradiol That Mimic Those Seen at the Onset of Spontaneous Puberty in Girls J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3039 - 3044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Soyka, W. P. Fairfield, and A. Klibanski Hormonal Determinants and Disorders of Peak Bone Mass in Children J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 3951 - 3963. [Full Text]
|
|
|
|
|
|
S. D. Chernausek, K. M. Attie, J. F. Cara, R. G. Rosenfeld, and J. Frane Growth Hormone Therapy of Turner Syndrome: The Impact of Age of Estrogen Replacement on Final Height J. Clin. Endocrinol. Metab., July 1, 2000; 85(7): 2439 - 2445. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Rubin Turner Syndrome and Osteoporosis: Mechanisms and Prognosis Pediatrics, August 1, 1998; 102(2): 481 - 485. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
