HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by STEHMAN, F. B. Articles by CREASMAN, W. T. Search for Related Content PubMed PubMed Citation Articles by STEHMAN, F. B. Articles by CREASMAN, W. T.

Early Stage I Carcinoma of the Vulva Treated With Ipsilateral Superficial Inguinal Lymphadenectomy and Modified Radical Hemivulvectomy: A Prospective Study of the Gynecologic Oncology Group

From the Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana; the Gynecologic Oncology Group, Buffalo, New York; the Department of Pathology, Henry Ford Hospital, Detroit, Michigan; and the Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina

Abstract

Although cure rates are high, the morbidity of radical operation for carcinoma of the vulva is substantial. Between 1983-1989, member institutions of the Gynecologic Oncology Group entered 155 patients in a prospective evaluation of modified radical hemivulvectomy and ipsilateral inguinal lymphadenectomy for clinical stage I vulvar cancer. Only patients with neoplastic thickness of 5 mm or less, without vascular space invasion, and negative inguinal lymph nodes were eligible for this study. There have been 19 recurrences and seven deaths from disease among the 121 eligible and evaluable patients. Patients whose disease recurred on the vulva were frequently (eight of ten patients) salvaged by further operation. Five of the seven deaths due to cancer occurred among patients whose first recurrence was in the groin. Acute and long-term morbidity as well as hospital stay were each less than in the Group's previous experience in a comparable patient population treated with radical vulvectomy and bilateral inguinal-femoral lymphadenectomy. There was a significantly increased risk of recurrence but not death when compared with these same historic controls. Modified radical hemivulvectomy and ipsilateral inguinal lymphadenectomy is an alternative to traditional radical operation for these selected patients with stage I carcinoma of the vulva. The number of patients who experienced recurrence in the operated groin is of concern and may be attributable to the decision to leave the femoral nodes intact.

This article has been cited by other articles:

				C. F. Levenback How Safe Is Sentinel Lymph Node Biopsy in Patients With Vulvar Cancer? J. Clin. Oncol., February 20, 2008; 26(6): 828 - 829. [Full Text] [PDF]

				A. G.J. Van der Zee, M. H. Oonk, J. A. De Hullu, A. C. Ansink, I. Vergote, R. H. Verheijen, A. Maggioni, K. N. Gaarenstroom, P. J. Baldwin, E. B. Van Dorst, et al. Sentinel Node Dissection Is Safe in the Treatment of Early-Stage Vulvar Cancer J. Clin. Oncol., February 20, 2008; 26(6): 884 - 889. [Abstract] [Full Text] [PDF]

				F. B. Stehman and K. Y. Look Carcinoma of the vulva. Obstet. Gynecol., March 1, 2006; 107(3): 719 - 733. [Abstract] [Full Text] [PDF]

				R. Rouzier, B. Haddad, F. Plantier, P. Dubois, M. Pelisse, and B.-J. Paniel Local Relapse in Patients Treated for Squamous Cell Vulvar Carcinoma: Incidence and Prognostic Value Obstet. Gynecol., December 1, 2002; 100(6): 1159 - 1167. [Abstract] [Full Text] [PDF]

				X. Matias-Guiu, E. Lerma, and J. Prat Current Topics in Pathology of Gynecologic Tumors: A Selective Review International Journal of Surgical Pathology, July 1, 1998; 6(3): 121 - 134. [Abstract] [PDF]