HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by BRADY, K. Articles by READ, J. A. Search for Related Content PubMed PubMed Citation Articles by BRADY, K. Articles by READ, J. A.

Risk of Chromosomal Abnormalities in Patients With Idiopathic Polyhydramnios

From the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington

Abstract

This prospective investigation was designed to assess the incidence of chromosomal abnormalities in patients with idiopathic polyhydramnios. Polyhydramnios was defined as 25 cm or greater in total vertical height in all four quadrants (amniotic fluid index) in any nonreferral patient (ie, primary care population) undergoing sonographic examination with a singleton pregnancy, normal fetal anatomical survey, normal glucose screening, and negative antibody screen. During the 2-year period from May 1,1988 through April 30, 1990, 5038 gravidas delivered at Madigan Army Hospital Center. Unexplained polyhydramnios was detected sonographically in 125 patients, an incidence of 2.5%. After obtaining informed written consent, amniocentesis was performed in all patients. Within this group (N=125), four chromosomal abnormalities (incidence of 3.2%) were detected. There were two trisomy 18 and two trisomy 21 fetuses. None of the four patients had maternal serum alpha-fetoprotein screening performed. The incidence of aneuploidy in patients with idiopathic polyhydramnios (3.2%) is much higher than the reported incidence of major karyotype abnormalities in live births (0.59%). We conclude that fetal chromosomal analysis should be considered in all obstetric patients with sonographic evidence of idiopathic polyhydramnios.

This article has been cited by other articles:

				J. S. Dashe, D. D. McIntire, R. M. Ramus, R. Santos-Ramos, and D. M. Twickler Hydramnios: Anomaly Prevalence and Sonographic Detection Obstet. Gynecol., July 1, 2002; 100(1): 134 - 139. [Abstract] [Full Text] [PDF]

				J. R. BIGGIO Jr, K. D. WENSTROM, M. B. DUBARD, and S. P. CLIVER Hydramnios Prediction of Adverse Perinatal Outcome Obstet. Gynecol., November 1, 1999; 94(5): 773 - 777. [Abstract] [Full Text] [PDF]