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Obstetrics & Gynecology 1990;75:131-133
© 1990 by The American College of Obstetricians and Gynecologists
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A MODIFIED TERMINOLOGY FOR CERVICAL INTRAEPITHELIAL NEOPLASIA

Ralph M. Richart, MD

From the Department of Pathology, Columbia University College of Physicians and Surgeons; and the Division of Obstetrical and Gynecological Pathology and Cytology, The Sloane Hospital for Women, New York, New York

Recent data are consistent with the concept that human papillomavirus (HPV) is etiologically important in the causation of cervical squamous cell cancer. There appear to be certain important events in the process of HPV infection and neoplasia. It is suggested that the terminology of the HPVrelated precursor lesions be modified and that two terms, rather than three, would best satisfy the requirements of both science and clinical care. The "early" lesions should be referred to as "low-grade cervical intraepithelial neoplasia (CIN) with HPV-related changes" and the lesions that have the features of cancer precursors as "high-grade CIN."




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