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Obstetrics & Gynecology 1989;74:658-662
© 1989 by The American College of Obstetricians and Gynecologists
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Binding of Epidermal Growth Factor and Insulin-Like Growth Factor I in Human Myometrium and Leiomyomata

PÄIVI TOMMOLA, MD, FREDRIKA PEKONEN, MD and EEVA-MARJA RUTANEN, MD

From the Minerva Institute for Medical Research, Kauniainen; and Jorvi Hospital, Espoo, Finland.

Samples of uterine myometrium and leiomyoma from 11 women were analyzed for the presence of epidermal growth factor receptors and insulin-like growth factor I receptors. In addition, the content of soluble insulin-like growth factor binding protein (IGF-BP/PP12) was measured in the tissue cytosols. Cell membrane preparations of myoma tissue bound significantly more insulin-like growth factor I than did those of adjacent normal myometrium, whereas myoma tissue bound less epidermal growth factor than did the normal myometrium. The differences in both insulin-like growth factor I and epidermal growth factor binding were due to changes in receptor concentration rather than to alterations hi receptor affinity. Neither myoma nor myometrial tissue contained detectable levels of insulin-like growth factor binding protein. The changes in epidermal growth factor and insulin-like growth factor I binding to the myometrium may play a role in the pathogenesis of uterine leiomyomata.




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