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Placental Isoferritin Measured by a Specific Monoclonal Antibody as a Predictive Marker for Preterm Contraction Outcome

From the Department of Obstetrics and Gynecology "B", Sapir Medical Center, Kfar Saba; and Rogoff-Wellcome Medical Research Institute, Beilinson Medical Center, Petah Tikva, and Sackler School of Medicine, Tel Aviv University, Israel.

The serum levels of placental isoferritin and normal ferritin in 25 women with preterm contractions (mean ± SE gestational age 28.8 ±4.7 weeks) were compared with those in 14 control women with uncomplicated pregnancies (29.1 ± 7.3 weeks). The serum concentration of placental isoferritin in women with preterm contractions (15.3 ± 6.2 U/mL) was significantly lower than that in normal pregnant women (87.6 ± 22.6 U/mL) (P = .005). The level of normal ferritin in women with preterm contractions (30.6 ± 4.16 ng/ml) was lower than that in women with normal pregnancies (67 ± 9.6 ng/mL) (P = .01); however, both were within the normal range. Serum placental isoferritin levels correlated with pregnancy outcome; low placental isoferritin (up to 10 U/mL) was a sensitive (71.5%) indicator of preterm labor. Low placental isoferritin had a positive predictive value of 59% and a negative predictive value of 71%. These results suggest that placental isoferritin may serve as a predictive marker for the prognosis of preterm contractions.

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