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Obstetrics & Gynecology 1989;74:357-360
© 1989 by The American College of Obstetricians and Gynecologists
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Ultrasonography Versus Amniotic Fluid Spectral Analysis: Are They Sensitive Enough to Predict Neonatal Complications Associated With Isoimmunization?

E ALBERT REECE, MD, SOPHIE W. COLE, MD, ROBERTO ROMERO, MD, SANDRO GABRIELLI, MD, THERESA Z. O'CONNOR, MPH and JOHN C. HOBBINS, MD

From the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and the Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut

Abstract

The modern management of pregnancy complicated by erythroblastosis fetal is is based on serial amniocenteses followed by either intrauterine transfusions or early delivery of affected infants, depending on the gestational age. A retrospective study was undertaken involving 92 isoimmunised pregnancies in which ultrasonography and amniotic fluid analyses were used to assess the relative predictive values for neonatal complications. Our data demonstrated that ultrasonography and optical density analyses were comparable in the evaluation of the isoimmunized pregnancy. The combined information from both these modalities did not increase the predictive value over that observed with either one alone. Both instruments were found to have high negative predictive values. However, neither method, used singly or in combination, was highly predictive of neonatal complications. In light of the low positive predictive values, caution should be excersized in using the results of amniotic fluid spectral analyses and /or ultrasound examinations for predicting perinatal complications






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Copyright © 1989 by the American College of Obstetricians and Gynecologists.