HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by KARRAM, M. M. Articles by BHATIA, N. J, Search for Related Content PubMed PubMed Citation Articles by KARRAM, M. M. Articles by BHATIA, N. J,

Urodynamic Changes Following Hormonal Replacement Therapy in Women With Premature Ovarian Failure

From the Divisions of Gynecologic Urology and Reproductive Endocrinology, Harbor-UCLA Medical Center and Cedars-Sinai Medical Center, UCLA School of Medicine, University of California, Los Angeles, California

Abstract

The mechanism by which estrogen supplementation improves the symptom of stress incontinence in postmenopausal women is unclear. Six women with proved premature ovarian failure were studied urodynamically before and after administration of oral and vaginal estrogen to study estradiol's effects on lower urinary tract function. Regardless of the mode of administration, estrogen supplementation did not produce any significant change in urethral pressure, functional length, or cystometric parameters. However, a significant increase in pressure transmission ratio (P<.05) to the proximal and mid-urethra was noted after the administration of vaginal estrogen cream. We conclude that estrogen alone, in the absence of aging and other known precipitating factors for stress incontinence, is of minimal significance in maintaining normal urinary tract physiology