HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by KLEMI, P. J. Articles by KIILHOLMA, P. Search for Related Content PubMed PubMed Citation Articles by KLEMI, P. J. Articles by KIILHOLMA, P.

Influence of Cellular DNA Content on Survival in Ovarian Carcinoma

From the Departments of Pathology, Radiotherapy, and Obstetrics and Gynecology, University Central Hospital of Turku, and from the Department of Pathology, University of Turku, Turku, Finland

Abstract

Flow cytometric analysis of nuclear DNA content was performed on paraffin-embedded tissue from 153 ovarian epithelial carcinomas.The DNA ploidy, DNA index, and S phase fraction were determined without knowing the final outcome of the patients. Fifty-one (38%) of the 134 classifiable histograms were considered to be diploid, 70 (52%) aneuploid, and 13 (10%) multiploid. The DNA index was a better prognostic factor for survival than DNA ploidy; 48% of the patients with a small DNA index (less than 1.3) survived for 5 years after the diagnosis, in contrast to 14% of the patients with a large DNA index (greater than 1.3) (P<.0001). Carcinomas with a small S phase fraction (less than 11%) were associated with favorable survival (P=.0002). In multivariate analysis, the size of the residual tumor at surgery (P<.001), the DNA index (P=.001), and the S phase fraction (P=.05) were the only significant independent prognostic factors. The results indicate that flow cytometric nuclear DNA content analysis provides important additional information for the estimation of survival in ovarian carcinoma