HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by LURAIN, J. R. Articles by CHMIEL, J. S. Search for Related Content PubMed PubMed Citation Articles by LURAIN, J. R. Articles by CHMIEL, J. S.

Prognostic Significance of Positive Peritoneal Cytology in Clinical Stage I Adenocarcinoma of the Endometrium

From the Section of Gynecologic Oncology of the Department of Obstetrics and Gynecology, the Biometry Section, and the Cancer Center, Northwestern University Medical School and Northwestern Memorial Hospital/Prentice Women's Hospital, Chicago, Illinois

Abstract

One hundred fifty-seven consecutive patients with clinical stage I endometrial adenocarcinoma who underwent primary surgical therapy between July 1979 and January 1986 were evaluated prospectively for malignant peritoneal cytology. No treatment was directed specifically for positive peritoneal cytology. Thirty patients (19%) had malignant peritoneal cytology. In univariate statistical analysis, positive cytology was significantly associated with depth of myometrial invasion (P =.02) and histopathology (P<.025), but not with disease recurrence (P=.33). Recurrence developed in five (17%) of 30 patients with positive cytology and 11 (9%) of 127 patients with negative cytology. Using multivariate analysis, the presence of extrauterine disease spread other than lymph node metastasis was the only variable significantly associated with time to recurrence (P=.009). When patients with poor prognostic factors (grade 3 tumors, deep myometrial invasion, tumors larger than 2 cm, positive lymph nodes, and other extrauterine disease spread) were excluded from analysis, malignant peritoneal cytology still had no influence on time to recurrence. Of the five patients with positive peritoneal cytology who had disease recurrence, only one recurrence arose within the peritoneal cavity. The presence of positive peritoneal cytology in clinical stage I endometrial adenocarcinoma does not appear to have independent prognostic significance and probably should not influence treatment decisions in the absence of other poor prognostic factors.

This article has been cited by other articles:

				R. Manfredi, P. Mirk, G. Maresca, P. A. Margariti, A. Testa, G. F. Zannoni, D. Giordano, G. Scambia, and P. Marano Local-Regional Staging of Endometrial Carcinoma: Role of MR Imaging in Surgical Planning Radiology, May 1, 2004; 231(2): 372 - 378. [Abstract] [Full Text] [PDF]

				Y. HIRAI, N. TAKESHIMA, T. KATO, and K. HASUMI Malignant Potential of Positive Peritoneal Cytology in Endometrial Cancer Obstet. Gynecol., May 1, 2001; 97(5): 725 - 728. [Abstract] [Full Text] [PDF]

				P. G. Rose Endometrial Carcinoma N. Engl. J. Med., August 29, 1996; 335(9): 640 - 649. [Full Text] [PDF]