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Obstetrics & Gynecology 1988;72:68-73
© 1988 by The American College of Obstetricians and Gynecologists
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Condylomatous Carcinoma of the Vulva With Special Reference to Human Papillomavirus DNA

GORDON O. DOWNEY, MD, TAKASHI OKAGAKl, MD, PhD, RONALD S. OSTROW, PhD, BARBARA A. CLARK, BS, LEO B. TWIGGS, MD and ANTHONY J. FARAS, PhD

From the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, the Department of Laboratory Medicine and Pathology, the Department of Microbiology, and the Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota

Abstract

Nine cases of condylomatous carcinoma (squamous cell carcinoma arising in condyloma acuminatum) of the vulva were studied for their clinical history, histopathology, and presence of human papillomavirus (HPV) DNA. Condylomatous carcinoma occurred primarily in an elderly population with a mean age of 70 years. There was an antecedent history of vulvar condyloma in 77%, with a median of nine months before the documentation of an invasive lesion. The disease had a good prognosis, with few recurrences and no metastasis or deaths from the disease. Human papillomavirus DNA was demonstrated to be present in 55% of these tumors by either filter or in situ hybridization techniques. Both HPV 6 and HPV 16 DNA were identified in an equal number of cases.




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