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Obstetrics & Gynecology 1988;72:31-34
© 1988 by The American College of Obstetricians and Gynecologists
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Karyotypes of 1142 Couples With Recurrent Abortion

MARIE-FRANCE PORTNOÏ, MD, NICOLE JOYE, MD, JACQUELINE VAN DEN AKKER, MD, GENEVIEVE MORLIER, MD and JEAN-LOUIS TAILLEMITE, MD

From the Laboratoire de Cytogenetique, Centre Hospitalo- Universitaire St. Antoine, Paris, France

Abstract

Cytogenetic analysis was performed on 1142 couples with recurrent pregnancy loss. The frequency of major chromosomal abnormalities per couple was 4.8%. Among 771 couples who had only abortions, the rate of rearrangement did not correlate with the number of abortions. The highest incidence of cytogenetic abnormalities (6.6%) was found in 256 couples with abortion and a normal child. With regard to pregnancy outcome, no unbalanced fetal karyotype was found in prenatal diagnoses, and 40 normal children were born. The risk of unbalanced fetal karyotype is therefore low, but probably high enough for these couples to be offered the possibility of a prenatal diagnosis.




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