HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by RAPKIN, A. J. Articles by SU, T.-P. Search for Related Content PubMed PubMed Citation Articles by RAPKIN, A. J. Articles by SU, T.-P.

Whole-Blood Serotonin in Premenstrual Syndrome

From the Departments of Obstetrics and Gynecology and Psychiatry and Biobehavioral Science, University of California, Los Angeles, Center for Health Sciences.

Abstract

Whole-blood serotonin levels in 14 subjects with well documented premenstrual syndrome and 13 age-matched controls were compared. Serotonin levels of premenstrual syndrome subjects were significantly lower during the last ten days of the menstrual cycle. No significant differences were noted in levels of serum estradiol and progesterone. Decreased serotonin is known to be associated with depression in humans, and nonhuman primates have exhibited abnormal behavioral profiles when given serotonin antagonists. The present observation suggests that the physiologic basis of premenstrual syndrome involves an alteration in serotonin metabolism.

This article has been cited by other articles:

				E. Serrano and J. J. K. Warnock Depressive Disorders Related to Female Reproductive Transitions Journal of Pharmacy Practice, October 1, 2007; 20(5): 385 - 391. [Abstract] [PDF]

				V. Dhingra, J. L. Magnay, P. M. S. O'Brien, G. Chapman, A. A. Fryer, and K. M. K. Ismail Serotonin Receptor 1A C(-1019)G Polymorphism Associated With Premenstrual Dysphoric Disorder Obstet. Gynecol., October 1, 2007; 110(4): 788 - 792. [Abstract] [Full Text] [PDF]

				J. A. J. Schmitt, B. L. Jorissen, L. Dye, C. R. Markus, N. E.P. Deutz, and W. J. Riedel Memory function in women with premenstrual complaints and the effect of serotonergic stimulation by acute administration of an alpha-lactalbumin protein J Psychopharmacol, July 1, 2005; 19(4): 375 - 384. [Abstract] [PDF]

				W.H. Cronje, A. Vashisht, and J.W.W. Studd Hysterectomy and bilateral oophorectomy for severe premenstrual syndrome Hum. Reprod., September 1, 2004; 19(9): 2152 - 2155. [Abstract] [Full Text] [PDF]

				C. Tassorelli, G. Sandrini, A. P. Cecchini, R. E. Nappi, G. Sances, and E. Martignoni Changes in Nociceptive Flexion Reflex Threshold Across the Menstrual Cycle in Healthy Women Psychosom Med, July 1, 2002; 64(4): 621 - 626. [Abstract] [Full Text] [PDF]

				E. W. Freeman, K. Rickels, S. J. Sondheimer, and M. Polansky Differential Response to Antidepressants in Women With Premenstrual Syndrome/Premenstrual Dysphoric Disorder: A Randomized Controlled Trial Arch Gen Psychiatry, October 1, 1999; 56(10): 932 - 939. [Abstract] [Full Text] [PDF]

				T.-P. Su, P. J. Schmidt, M. Danaceau, D. L. Murphy, and D. R. Rubinow Effect of Menstrual Cycle Phase on Neuroendocrine and Behavioral Responses to the Serotonin Agonist m-Chlorophenylpiperazine in Women with Premenstrual Syndrome and Controls J. Clin. Endocrinol. Metab., April 1, 1997; 82(4): 1220 - 1228. [Abstract] [Full Text] [PDF]

				A. J. Rapkin, D. Shoupe, A. Reading, K. K. Daneshgar, L. Goldman, Y. Bohn, D. W. Brann, and V. B. Mahesh Decreased Central Opioid Activity in Premenstrual Syndrome: Luterinizing Hormone Response to Naloxone Reproductive Sciences, March 1, 1996; 3(2): 93 - 98. [Abstract] [PDF]