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Relationship Between Fetal Growth and Maternal Fructosamine in Diabetic Pregnancy

Postgraduate School of Obstetrics and Gynaecology, National Womens Hospital, and the Department of Clinical Biochemistry, Green Lane Hospital, Auckland, New Zealand.

Abstract

We studied 30 diabetic pregnant women to compare serum fructosamine concentrations at different stages of gestation with fetal growth (as determined by ultrasonography) and with birth weight. Serum fructosamine levels in mothers of macrosomic infants were significantly higher (P < .05) during the first trimester of pregnancy as compared with mothers of normal birth weight infants. Moreover, first-trimester fructosamine concentrations correlated significantly with birth weight ratio (r = 0.68, P < .001) and with ultrasound measurements of fetal abdominal circumference and femur length. The fetus destined to be macrosomic had an enlarged abdomen in the second trimester, often before 20 weeks' gestation. We conclude that maternal diabetic control during early gestation has an important influence on fetal growth and contributes to the development of fetal macrosomia.