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Obstetrics & Gynecology 1987;70:220-224
© 1987 by The American College of Obstetricians and Gynecologists
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Cisplatin, Vinblastine, and Bleomycin Combination Chemotherapy in Endodermal Sinus Tumor of the Ovary

CRISTIANA SESSA, MD, CRISTINA BONAZZI, MD, FABIO LANDONI, MD, SERGIO PECORELLI, MD, ENRICO SARTORI, MD and COSTANTINO MANGIONI, MD

Mario Negri Institute for Pharmacological Research, Milan, the Department of Obstetric and Gynecology, S. Cerardo Hospital, Monza, University of Milan, and the Department of Obstetrics and Gynecology, University of Brescia, Italy.

Abstract

The combination of cisplatin, vinblastine, and bleomycin was administered to 13 previously untreated patients with pure endodermal sinus tumor of the ovary. Twelve had unilateral salpingo-oophorectomy as initial surgery. Among 11 women whose alpha-fetoprotein (AFP) levels returned to normal after cisplatin, vinblastine, and bleomycin therapy, nine are alive with no evidence of disease after periods of 20 months to six years and two months. In two patients, AFP levels returned to normal only after the introduction of different combination chemotherapies. Hematologic toxicity was moderate. Pulmonary toxicity due to bleomycin occurred in two cases. All menstruating patients resumed normal menstrual function after the interruption of chemotherapy. Two patients delivered normal term infants.




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