HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by SARAVOLATZ, L D Articles by DRUKKER, B. Search for Related Content PubMed PubMed Citation Articles by SARAVOLATZ, L D Articles by DRUKKER, B.

Comparison of Intravenous Administration With Intrauterine Irrigation With Ceforanide for Nonelective Cesarean Section

From the Division of Infectious Diseases and Hospital Epidemiology, Department of Obstetrics, Henry Ford Hospital, Detroit, Michigan; and the Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, Michigan

Abstract

A randomized, prospective, double-blind study was designed to compare intravenous administration with intrauterine irrigation using an extended half-life (t_l/2=three hours) cephalosporin, ceforanide. Patients included in the study had a nonelective cesarean section with rupture of membranes for three hours or longer. Sixty-four patients received a single dose of ceforanide immediately after clamping the umbilical cord. Patients were similar in both groups in age, weight, length of labor, and duration of ruptured membranes. The group receiving the intravenous ceforanide had a significantly shorter duration of surgery than the patients receiving the intrauterine ceforanide. Endometritis infection rates were similar, 11.8% (intravenous) versus 11.1% (intrauterine), P>.1. Serum levels were as much as tenfold higher in the intravenous group versus the intrauterine group. Intrauterine irrigation with an antimicrobial agent provided no advantage over systemic administration.