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Obstetrics & Gynecology 1985;66:S93
© 1985 by The American College of Obstetricians and Gynecologists
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Development of Ovarian Carcinoma in a Cyclosporin A Immunosuppressed Patient

RAYMOND MAUNG, MD, ALFREDO PINTO, MD, D. IAN ROBERTSON, MD, PhD, GAVIN C. E. STUART, MD, JOHN K. KLASSEN, MD and RONALD B. HONS, MD

Departments of Pathology, Obstetrics and Gynecology, and Medicine, University of Calgary, and Foothills Hospital, Calgary, Alberta, Canada.

This is the first report of an ovarian carcinoma developing in a patient immunosuppressed by Cyclosporin A. Thirteen months before the diagnosis of malignancy, the patient received a living related donor kidney transplant whose rejection was controlled by Cyclosporin A and prednisone. The tumor was rapidly fatal five weeks from diagnosis. The literature on malignant transformation in the immunosuppressed patient is reviewed with emphasis on a gynecologic perspective.




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