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Obstetrics & Gynecology 1985;65:356-360
© 1985 by The American College of Obstetricians and Gynecologists
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Metabolic Disturbances During Intravenous Use of Ritodrine: Increased Insulin Levels and Hypokalemia

ANTONIO CANO, MD, ISABEL TOVAR, PhD, JUAN JOSÉ PARRILLA, MD and LORENZO ABAD, MD

From the Department of Obstetrics and Gynecology, Facultad de Medicina, Espinardo;and the Department of Biochemistry, C. S. Virgen la Arrixaca, El Palmar (Murcia), Spain

Abstract

The role played by insulin and the adrenergic system in the development of hypokalemia due to intravenous ritodrine has been evaluated. Fifteen women presenting with premature labor (group 1) were treated with ritodrine infusion, whereas seven pregnant women not in labor (group 2) were given 100 g glucose per ps to induce hyperinsulinemia without participation of ritodrine. Serum glucose, insulin, potassium, sodium, chloride, and calcium were measured hourly. Whereas insulin levels were higher in group 2, potassium decreased markedly and significantly only in group 1. It is concluded that ritodrine-induced hypokalemia, that results partially from hyperinsulinemia, is mostly determined by other factors and is possibly a consequence of direct ß-adrenoceptor stimulation. Significant hypocalcemia of unexplained origin was observed with ritodrine. (Obstet Gynecol 65:356, 1985)




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R. S. BLACK, C. LEES, C. THOMPSON, A. PICKLES, and S. CAMPBELL
Maternal and Fetal Cardiovascular Effects of Transdermal Glyceryl Trinitrate and Intravenous Ritodrine
Obstet. Gynecol., October 1, 1999; 94(4): 572 - 576.
[Abstract] [Full Text] [PDF]


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