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Obstetrics & Gynecology 1984;64:503-509
© 1984 by The American College of Obstetricians and Gynecologists
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Structural and Functional Evidence for the Denervation of Human Myometrium During Pregnancy

MATTS WIKLAND, MD, BO LINDBLOM, MD, PhD, ANNICA DAHLSTRÖM, MD, PhD and KENNETH G. HAGLID, MD, PhD

From the Department of Obstetrics and Gynecology and the Department of Histology, University of Göteborg, Göteborg, Sweden

Abstract

The neuronal influence of the contractility of the term-pregnant human uterus was studied by pharmacologic and histochemical methods. By the use of adrenergic and cholinergic antagonists or tetrodotoxin it was demonstrated that the contractile response of superfused myometrial strips from the term-pregnant uterus to electrofield stimulation was not influenced by any neuronal factor. Using an indirect immunofluorescence technique with an antiserum to the glial and Schwann cell specific S-100 protein, a marked paucity of nerve fibers was demonstrated in myometrial strips from the term-pregnant uterus as compared with the nonpregnant uterus. It is concluded that the described decrease of nerve fibers within the myometrium of the pregnant uterus may be of importance for the myometrial activity during pregnancy and parturition.




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Copyright © 1984 by the American College of Obstetricians and Gynecologists.