Obstetrics & Gynecology Email Alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Obstetrics & Gynecology 1984;64:46-48
© 1984 by The American College of Obstetricians and Gynecologists
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WEINER, C. P.
Right arrow Articles by WALLEMARK, C.-B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WEINER, C. P.
Right arrow Articles by WALLEMARK, C.-B.

Fibrin Generation in Normal Pregnancy

CARL P. WEINER, MD, HAU KWAAN, MD, WALTER W. HAUCK, PhD, FRED J. DUBOE, MD, MICHAEL PAUL, MD and CARL-BERTIL WALLEMARK, MS

From the Departments of Obstetrics and Gynecology, Medicine, Community Health and Preventive Medicine, and the Cancer Center, Northwestern University Memorial Hospitals, Prentice Women's Hospital, 333 East Superior, Chicago, Illinois.

Both clinical and laboratory findings suggest that pregnancy constitutes a hypercoagulable condition; yet none of the observed laboratory changes are specific for thrombosis. An essential step involves thrombin-mediated fibrin generation. In the process, fibrinopeptide A (FPA) is cleaved from fibrinogen. Using a radioimmune assay, FPA was determined prospectively in a longitudinal and cross-sectional fashion. Fibrinopeptide A increased significantly over control by the end of the first trimester, from 1.3 ng/ml to 2.8 ng/ml. It continued to increase until 30 to 32 weeks' gestation and then plateaued at 4.3 to 4.7 ng/ml. In the immediate postpartum period, FPA remains elevated. In conclusion, thrombin generation as reflected in FPA production is increased throughout pregnancy, thus confirming a hypercoagulable milieu.




This article has been cited by other articles:


Home page
 Eur Heart JHome page
M. de Swiet
Review Article: Management of pulmonary embolus in pregnancy
Eur. Heart J., October 1, 1999; 20(19): 1378 - 1385.
[PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
S. C. L. Koh, S. Arulkumaran, A. Biswas, and S. S. Ratnam
The Influence of Labor and Placental Separation on Hemostasis in Term Pregnancy
Clinical and Applied Thrombosis/Hemostasis, October 1, 1998; 4(4): 262 - 267.
[Abstract] [PDF]

Home page
 NEJMHome page
M. R. Toglia and J. G. Weg
Venous Thromboembolism during Pregnancy
N. Engl. J. Med., July 11, 1996; 335(2): 108 - 114.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 by the American College of Obstetricians and Gynecologists.