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Obstetrics & Gynecology 1984;64:131-132
© 1984 by The American College of Obstetricians and Gynecologists
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CIRCULATING PLACENTAL PROTEINS IN PREGNANCIES COMPLICATED BY RH ISOIMMUNIZATION

Jau-Nan Lee, MB, MD, PhD, Su -Cheng Huang, MD, Pei-Chuan Ouyang, MD and Tim Chard, MD

Nine pregnant women with Rh isoimmunization who delivered newborns with hydrops fetalis were studied. The placental proteins, pregnancy specific {gamma}-glycoprotein (Sp1), human placental lactogen, and placental protein 5 (PP5) were measured in maternal serum by radioimmunoassays. The results indicate that both the serum human placental lactogen and PP5 levels were significantly higher than those observed in normal pregnancy. The strikingly higher circulating PP5 levels found in all nine patients with Rh isoimmunization studied suggests that serum PP5 may be specifically elevated in pregnant patients with Rh isoimmunization and hydrops fetalis.






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