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Obstetrics & Gynecology 1984;63:S86
© 1984 by The American College of Obstetricians and Gynecologists
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Adrenal Hypofunction and Trisomy 18

MICHAEL TURNER, MB and COLM O'HERLIHY, MD

Department of Obstetrics and Gynecology, National Maternity Hospital, Holles Street, Dublin 2, Ireland.

Abstract

Three cases of trisomy 18 are described, each with evidence of diminished fetoplacental function, specifically reduced 24-hour maternal urinary estrogen. All three infants died within three months and showed gross and microscopic evidence of hypoplasia of the fetal adrenal cortical zone. This abnormality is consistent with and helps explain the increased incidence of obstetric intervention and prolonged pregnancy in this syndrome.






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Copyright © 1984 by the American College of Obstetricians and Gynecologists.