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Management of Severe Postpartum Hemorrhage With a Prostaglandin F₂ Analogue

From the Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, Texas; and The Upjohn Company, Kalamazoo, Michigan.

Presented is a three-year study using a 15-methyl analogue of prostaglandin F₂, in the management of severe postpartum hemorrhage due to uterine atony in patients who were unresponsive to conventional therapies. Fifty-four patients were entered into the study, but 51 were analyzed for efficacy. Successful control of postpartum hemorrhage occurred in 86%. Of the seven in whom therapy failed and who subsequently required surgical therapy, four had chorioamnionitis. Six subjects had intramyometrial injection of the agent, with dramatic results in five. Mild transient side effects occurred in less than 10% of subjects.

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