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Correlation Between Maternal and Fetal Immunoglobulin E Levels

From the Department of Obstetrics and Gynecology; the Section of Allergy and Immunology, the Department of Pediatrics; and the Department of Medicine, The New York Hospital-Cornell Medical Center; and the Department of Clinical Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York

Abstract

Immunoglobulin E (IgE) concentrations were measured in 157 paired samples of maternal-fetal sera. A correlation was found between maternal and fetal IgE levels, in contrast to earlier reports dealing with smaller series. The correlation is probably not due to placental transfer of maternal IgE but rather to genetic factors. The possible role of IgE in the fetal immune response is discussed.

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