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Significance of Serum Tumor Markers in Patients With Carcinoma of the Ovary

From the Department of Obstetrics and Gynecology, National Defense Medical College, Namiki 3-2, Tokoroznioa, Saitama 359, Japan

Abstract

A comparison of preoperative serum tumor markers (lactate dehydrogenase, lactate dehydrogenase isoenzymes, -hydroxybutyrate dehydrogenase, alkaline phosphatase, aldolase, Ieucine aminopeptidase, cholinesterase, erythrocyte sedimentation reaction, carcinoembryonic antigen, -fetoprotein, and ß₂-microglobulin) was made in 76 patients with ovarian or uterine cancer. Sixty-six patients with benign ovarian tumor served as control subjects. From analysis of each tumor marker the greatest positive results were obtained with the markers ß₂-microglobulin (57.1%), lactate dehydrogenase (53.1%), and hydroxybutyrate dehydrogenase (46.2%) for patients with carcinoma of the ovary. The use of these marker combinations in all ovarian cancer patients resulted in a marked increase of the positive rate from 57.1 to 85.2%. In stage I cases, the positive rate increased from 40.6 to 63.6%.