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Reversible Tubular Lesion in Pregnancy-Induced Hypertension Detected by Urinary ß₂-Microglobulin

From the Departments of Obstetrics and Gynecology and Chemical Pathology, Faculty of Medicine, University of Natal, P.O. Box 17039, Congella, Durban, South Africa

Abstract

Serum and urine ß₂microglobulin concentrations were measured in 17 primigravidas with mild pregnancy-induced hypertension and nine normotensive control patients matched for gestational age. Serum ß₂-microglobulin and creatinine clearance values were not different between the two groups but urinary excretion of ß₂-microglobulin was three times higher in the hypertensive patients. This difference disappeared within seven days of delivery. These results indicate that a reversible renal tubular lesion occurs in pregnancy-induced hypertension even in the absence of detectable proteinuria.