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Obstetrics & Gynecology 1984;63:396-400
© 1984 by The American College of Obstetricians and Gynecologists
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Uterine and Cardiovascular Effects of Fenoterol and Hexoprenaline In Prostaglandin F2{alpha}-Induced Labor in Humans

JEFFREY LIPSHITZ, MB and ELSPETH M. LIPSHITZ

Division of Maternal/Fetal Medicine, Department of Obstetrics and Gynecology, University of Tennessee College of Medicine, Memphis, Tennessee.

The effectiveness of the ß-sympathomimetic drugs in prostaglandin-induced labor in humans is uncertain. To assess and compare their uterine and cardiovascular effects, fenoterol (2.5 µg/minute) and hexoprenaline (0.38 µg/manute) were alternatively infused for 20 minutes in each of 12 patients having prostaglandin F2{alpha} inductions of labor at term. Uterine activity was reduced to less than 29% of the pretreatment value. For similar tocolytic effects, hexoprenaline produced a significantly lesser effect on maternal heart rate than fenoterol (P == .005).






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Copyright © 1984 by the American College of Obstetricians and Gynecologists.