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Influence of Prostaglandins on Contractility of the Isolated Human Cervical Muscle

Department of Obstetrics and Gynecology, University of Göteborg, Sahlgrenska sjukhuset, S-413 45 Göteborg, Sweden.

The contractile activity of smooth muscle from the pregnant and nonpregnant human cervix uteri was studied in organ bath experiments. Several patterns of spontaneous activity with varying frequency and amplitude were observed. Prostaglandin E₂ inhibited muscle activity in a concentration-dependent manner, and total inhibition was achieved in pregnant tissue at extremely low concentrations. Prostaglandin F₂, on the other hand, did not influence spontaneous contractions. Prostaglandin I₂ and 6-keto-prostaglandin F₁ had an inhibitory effect but only at comparatively high concentrations. 5,8,11,14-Eicosatetraynoic acid and indomethacin abolished spontaneous contractions, indicating a regulatory influence of endogenous prostanoids on cervical contractility. The extreme sensitivity to prostaglandin E₂ and enhancement of its action during early pregnancy provide evidence for a specific role of this compound in controlling cervical smooth muscle activity in the human female.

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