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Autoimmune Phenomena in Infertile Patients With Endometriosis

Reproductive Endocrinology Unit, Departments of Obstetrics and Gynecology, Pediatrics, Biochemistry, and Clinical Pathology, Upstate Medical Center, Syracuse, New York.

To assess the presence of autoimmune factors in patients with endometriosis, endometrial homogenates, peritoneal fluid, and serum were evaluated in 23 patients with endometriosis and 22 control subjects. The methods used were Ouchterlony immunodiffusion, immunoelectrophoresis, polyacylamide gel electrophoresis, and radial immunodiffusion. The study demonstrated precipitation lines between endometrial homogenates and serum from some endometriosis patients but not from the control subjects. Immunoelectrophoresis demonstrated precipitation lines at ß-globulin position when endometrial homogenates were used against serum of patients with endometriosis and with goat antihuman serum. It is suggested that an antigen, possibly a glycoprotein, is present in the endometrial homogenates. Radial immunodiffusion studies for immunoglobulins (Ig) G, A, and M and complement components C₃c and C₄ showed significantly higher concentrations of C₃c and C₄ in serum and peritoneal fluid of patients with endometriosis than the control subjects (P < .05). There was no significant difference in concentration of IgG, A, M, factor B, and properdin.

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